:root {
  --aqua-blue: #3083dd;
  --aqua-blue-2: #577fee;
  --aqua-soft: #eef4ff;
  --aqua-ink: #17212b;
  --aqua-muted: #64748b;
  --aqua-line: rgba(48, 131, 221, 0.16);
  --aqua-panel: rgba(255, 255, 255, 0.94);
  --aqua-shadow: 0 16px 38px rgba(26, 55, 73, 0.12);
}

.page-header {
  background: linear-gradient(135deg, #3083dd, #a3c4f3);
}

main {
  max-width: 1280px;
  margin: 0 auto;
  padding: 10px 22px 56px;
  color: var(--aqua-ink);
}

main > section,
.query-panel,
.search-panel,
.filter-panel,
.results-section,
.table-section,
.data-section,
.control-panel {
  background: var(--aqua-panel);
  border: 1px solid var(--aqua-line);
  box-shadow: var(--aqua-shadow);
  margin-bottom: 16px;
  padding: 20px;
}

main > section:first-child {
  display: grid;
  gap: 14px;
  align-items: end;
}

label {
  display: block;
  color: var(--aqua-muted);
  font-size: 0.82rem;
  font-weight: 800;
  letter-spacing: 0.06em;
  text-transform: uppercase;
  margin-bottom: 7px;
}

select,
input[type="text"],
input[type="number"],
input:not([type]),
textarea {
  width: 100%;
  min-height: 42px;
  box-sizing: border-box;
  border: 1px solid rgba(48, 131, 221, 0.28);
  background: #fff;
  color: var(--aqua-ink);
  padding: 9px 11px;
  font-size: 0.96rem;
  outline: none;
}

select:focus,
input:focus,
textarea:focus {
  border-color: var(--aqua-blue);
  box-shadow: 0 0 0 4px rgba(48, 131, 221, 0.13);
}

button,
.search-btn,
.detail-btn {
  border: 0;
  background: var(--aqua-blue);
  color: #fff;
  min-height: 38px;
  padding: 8px 15px;
  font-weight: 850;
  cursor: pointer;
  transition: transform 0.18s ease, box-shadow 0.18s ease, background 0.18s ease;
}

button:hover,
.search-btn:hover,
.detail-btn:hover {
  transform: translateY(-2px);
  background: #256fbc;
  box-shadow: 0 10px 22px rgba(48, 131, 221, 0.24);
}

button:disabled {
  opacity: 0.45;
  cursor: not-allowed;
  transform: none;
  box-shadow: none;
}

h2,
h3 {
  color: #1f3f68;
  margin-top: 0;
}

.table-wrap,
.table-container,
.result-table,
.results-table {
  overflow: auto;
  border: 1px solid rgba(38, 85, 104, 0.12);
  background: #fff;
}

table {
  width: 100%;
  border-collapse: collapse;
  background: #fff;
}

th,
td {
  padding: 11px 12px;
  border-bottom: 1px solid rgba(38, 85, 104, 0.1);
  text-align: left;
  white-space: nowrap;
}

th {
  position: sticky;
  top: 0;
  z-index: 1;
  background: #f5f8ff;
  color: #254a77;
  font-size: 0.84rem;
  text-transform: uppercase;
  letter-spacing: 0.04em;
}

tbody tr:hover {
  background: rgba(48, 131, 221, 0.05);
}

a {
  color: var(--aqua-blue-2);
  text-decoration: none;
  font-weight: 750;
}

a:hover {
  text-decoration: underline;
}

.empty {
  text-align: center;
  color: var(--aqua-muted);
  padding: 28px 12px !important;
}

.pagination,
.pager {
  display: flex;
  align-items: center;
  justify-content: flex-end;
  gap: 10px;
  color: var(--aqua-muted);
  margin-top: 12px;
}

@media (max-width: 1000px) {
  main > section:first-child {
    grid-template-columns: repeat(2, minmax(0, 1fr));
  }
}

@media (max-width: 640px) {
  main {
    padding: 8px 12px 36px;
  }

  main > section:first-child {
    grid-template-columns: 1fr;
  }
}

/* ========== Variation search pages polish ========== */
main.container {
  max-width: 1800px;
  margin: 24px auto 36px;
  padding: 26px 30px;
  background: linear-gradient(180deg, rgba(255, 255, 255, 0.98), rgba(246, 250, 255, 0.96));
  border: 1px solid rgba(32, 112, 142, 0.12);
  border-radius: 14px;
  box-shadow: 0 14px 34px rgba(23, 54, 77, 0.09);
}

main.container .selector {
  max-width: none;
  display: flex;
  justify-content: flex-start;
  align-items: center;
  gap: 14px;
  flex-wrap: wrap;
  margin: 0 0 22px;
  padding: 18px 22px;
  font-family: "Segoe UI", Arial, sans-serif;
  font-size: 20px;
  font-weight: 500;
  background: linear-gradient(135deg, #f0f4ff 0%, #e8f0fe 50%, #f5f0ff 100%);
  border: 1px solid rgba(79, 109, 212, 0.1);
  border-radius: 16px;
  box-shadow: 0 2px 12px rgba(79, 109, 212, 0.08);
}

main.container .selector label,
.plot-toolbar label {
  color: #3a4f8a;
  font-size: 20px;
  font-weight: 600;
  letter-spacing: 0.2px;
  margin: 0;
  text-transform: none;
}

main.container .selector select,
main.container .selector input[type="text"],
main.container .selector input[type="number"],
.plot-toolbar select {
  width: auto;
  min-width: 200px;
  min-height: 42px;
  padding: 8px 14px;
  box-sizing: border-box;
  border: 2px solid #d0d7f0;
  border-radius: 10px;
  background-color: #fff;
  color: #333;
  font-size: 20px;
  box-shadow: 0 1px 4px rgba(0,0,0,0.03);
  transition: all 0.25s ease;
}

main.container #species-select,
main.container #chromosome-select,
main.container #search-input,
main.container #region-start,
main.container #region-end,
main.container #type-filter {
  width: auto;
  min-width: 200px;
  min-height: 42px;
  padding: 8px 14px;
  box-sizing: border-box;
  border: 2px solid #d0d7f0;
  border-radius: 10px;
  background-color: #fff;
  color: #333;
  font-size: 20px;
  box-shadow: 0 1px 4px rgba(0,0,0,0.03);
  transition: all 0.25s ease;
}

main.container #species-select,
main.container #chromosome-select,
main.container #type-filter {
  padding: 8px 36px 8px 12px;
  background-image: url("data:image/svg+xml,%3Csvg xmlns='http://www.w3.org/2000/svg' width='11' height='11' viewBox='0 0 12 12'%3E%3Cpath fill='%235a6fc4' d='M6 8L1 3h10z'/%3E%3C/svg%3E");
  background-repeat: no-repeat;
  background-position: right 12px center;
  -webkit-appearance: none;
  appearance: none;
  cursor: pointer;
}

main.container #region-start,
main.container #region-end {
  max-width: none;
}

main.container .selector select,
.plot-toolbar select {
  padding: 8px 36px 8px 12px;
  background-image: url("data:image/svg+xml,%3Csvg xmlns='http://www.w3.org/2000/svg' width='11' height='11' viewBox='0 0 12 12'%3E%3Cpath fill='%235a6fc4' d='M6 8L1 3h10z'/%3E%3C/svg%3E");
  background-repeat: no-repeat;
  background-position: right 12px center;
  -webkit-appearance: none;
  appearance: none;
  cursor: pointer;
}

main.container .selector input[type="number"] {
  min-width: 150px;
}

main.container .selector select:hover,
main.container .selector input:hover,
.plot-toolbar select:hover,
main.container #species-select:hover,
main.container #chromosome-select:hover,
main.container #search-input:hover,
main.container #region-start:hover,
main.container #region-end:hover,
main.container #type-filter:hover {
  border-color: #8fa4e8;
  box-shadow: 0 2px 10px rgba(79, 109, 212, 0.12);
}

main.container .selector select:focus,
main.container .selector input:focus,
.plot-toolbar select:focus,
main.container #species-select:focus,
main.container #chromosome-select:focus,
main.container #search-input:focus,
main.container #region-start:focus,
main.container #region-end:focus,
main.container #type-filter:focus {
  outline: none;
  border-color: #5b6fd4;
  box-shadow: 0 0 0 3px rgba(91, 111, 212, 0.12);
}

main.container .selector input::placeholder {
  color: #aab2c5;
  font-size: 20px;
}

main.container #search-btn {
  min-height: 42px;
  padding: 9px 24px;
  border: none;
  border-radius: 10px;
  background: linear-gradient(135deg, #5b8def, #4a7de0);
  color: #fff;
  cursor: pointer;
  font-size: 20px;
  font-weight: 600;
  letter-spacing: 0.3px;
  box-shadow: 0 3px 10px rgba(79, 109, 212, 0.25);
  transition: all 0.25s ease;
}

main.container #search-btn:hover {
  transform: translateY(-2px);
  box-shadow: 0 6px 16px rgba(79, 109, 212, 0.32);
  background: linear-gradient(135deg, #4a7de0, #3e6dd4);
}

main.container #search-btn:active {
  transform: translateY(0);
  box-shadow: 0 2px 6px rgba(79, 109, 212, 0.2);
}

main.container .plot-container {
  position: relative;
  overflow: hidden;
  padding: 24px;
  margin-bottom: 24px;
  background: linear-gradient(135deg, rgba(255, 255, 255, 0.98), rgba(235, 247, 255, 0.95));
  border: 1px solid rgba(32, 112, 142, 0.14);
  border-radius: 14px;
  box-shadow: 0 16px 36px rgba(23, 54, 77, 0.1);
}

main.container .plot-container::before {
  content: "";
  position: absolute;
  inset: 0 0 auto;
  height: 4px;
  background: linear-gradient(90deg, #23a6b7, #4f8fe8, #7bbf8a);
}

.plot-header {
  display: flex;
  justify-content: space-between;
  align-items: flex-start;
  gap: 18px;
  padding-bottom: 16px;
  margin-bottom: 14px;
  border-bottom: 1px solid rgba(32, 112, 142, 0.12);
}

.section-kicker {
  display: inline-flex;
  margin-bottom: 6px;
  color: #067485;
  font-size: 0.82rem;
  font-weight: 850;
  letter-spacing: 0.08em;
  text-transform: uppercase;
}

main.container .plot-container h3 {
  margin: 0 0 8px;
  color: #12374d;
  font-size: 26px;
  font-weight: 850;
  letter-spacing: 0;
  -webkit-text-fill-color: currentColor;
  background: none;
}

.plot-header p {
  margin: 0;
  color: #496d84;
  font-size: 16px;
  font-weight: 600;
}

.variant-stats {
  display: flex;
  justify-content: flex-end;
  gap: 10px;
  flex-wrap: wrap;
}

.variant-stats span {
  display: inline-flex;
  align-items: baseline;
  gap: 6px;
  padding: 8px 12px;
  border-radius: 8px;
  color: #496d84;
  background: rgba(255, 255, 255, 0.76);
  border: 1px solid rgba(32, 112, 142, 0.12);
  font-size: 14px;
  font-weight: 700;
}

.variant-stats strong {
  color: #075f6e;
  font-size: 22px;
  line-height: 1;
}

.plot-toolbar {
  display: inline-flex;
  align-items: center;
  gap: 10px;
  flex-wrap: wrap;
  margin-bottom: 14px;
  padding: 10px 12px;
  border-radius: 12px;
  background: rgba(255, 255, 255, 0.72);
  border: 1px solid rgba(32, 112, 142, 0.1);
}

#variation-container {
  width: 100%;
  min-height: 440px;
  border-radius: 12px;
  border: 1px solid rgba(32, 112, 142, 0.12);
  background:
    radial-gradient(circle at 15% 18%, rgba(35, 166, 183, 0.09), transparent 28%),
    radial-gradient(circle at 84% 16%, rgba(79, 143, 232, 0.12), transparent 30%),
    linear-gradient(180deg, rgba(250, 253, 255, 0.96), rgba(243, 249, 255, 0.98));
  box-shadow: inset 0 1px 8px rgba(23, 54, 77, 0.04);
}

main.container .table-container {
  max-width: none;
  padding: 0;
  overflow: auto;
  border: 1px solid rgba(32, 112, 142, 0.14);
  border-radius: 14px;
  background: #fff;
  box-shadow: 0 10px 26px rgba(23, 54, 77, 0.08);
}

main.container .table-container h3 {
  margin: 0;
  padding: 18px 20px;
  color: #12374d;
  font-size: 22px;
  font-weight: 850;
  border-bottom: 1px solid rgba(32, 112, 142, 0.12);
}

main.container #variation-table th {
  background: #edf6ff;
  color: #254a77;
  font-size: 15px;
  font-weight: 850;
}

main.container #variation-table td {
  font-size: 15px;
  color: #253348;
}

main.container .pagination {
  justify-content: center;
  gap: 12px;
  padding: 12px 0 0;
  background: transparent;
  border: 0;
  box-shadow: none;
}

main.container .pagination button {
  min-height: 38px;
  padding: 8px 16px;
  border-radius: 8px;
  background: #4a90e2;
  color: #fff;
}

main.container .pagination button:disabled {
  background: #cbd5e1;
  box-shadow: none;
}

@media (max-width: 900px) {
  main.container {
    margin: 14px 12px 30px;
    padding: 16px 14px;
  }

  main.container .selector,
  .plot-header {
    display: grid;
  }

  main.container .selector select,
  main.container .selector input[type="text"],
  main.container .selector input[type="number"],
  main.container #search-btn,
  .plot-toolbar,
  .plot-toolbar select {
    width: 100%;
  }

  .variant-stats {
    justify-content: flex-start;
  }

  #variation-container {
    min-height: 380px;
  }
}